vicissitudes

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vi|cis|si|tudes /vɪs'ɪsɪtjuːdz, AM -tuːdz/
[N-PLURAL] oft N of n
You use vicissitudes to refer to changes, especially unpleasant ones, that happen to someone or something at different times in their life or development. (FORMAL)
Whatever the vicissitudes of her past life, Jill now seems to have come through.

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